NDLI: Immunological Abnormalities in a Child with Constitutional Aplastic Anemia

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Immunological Abnormalities in a Child with Constitutional Aplastic Anemia

Content Provider	Scilit
Author	Dohlsten, Mikael Carlsson, Roland Hedlund, Gunnar Sjögren, Hans Olov Békássy, Albert N. Garwicz, Stanislaw
Copyright Year	1986
Description	Journal: Pediatric hematology and oncology This case report describes a child with severe constitutional hypoplastic anemia and Seckel's syndrome. Immunological analysis on mononuclear peripheral blood cells revealed an abnormally low ratio of T-helper to T-suppressor/cytotoxic cells and a highly increased number of HLA-DR-positive T suppressor/cyiotoxic cells. Interferon-y and interleukin-2 production by mitogen-stimulated peripheral blood mononuclear cells was slightly reduced, and no spontaneous production of these lymphokines was seen. The immunological abnormalities demonstrated in this case of constitutional aplastic anemia may indicate common features with acquired aplastic anemia.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08880018609031204
Ending Page	96
Page Count	8
Starting Page	89
ISSN	08880018
e-ISSN	15210669
DOI	10.3109/08880018609031204
Journal	Pediatric hematology and oncology
Issue Number	1
Volume Number	3
Language	English
Publisher	Informa UK Limited
Publisher Date	1986-01-01
Access Restriction	Open
Subject Keyword	Journal: Pediatric hematology and oncology Pediatrics and Child Health Immunological Abnormalities Constitutional Aplastic Anemia
Content Type	Text
Subject	Hematology Pediatrics, Perinatology and Child Health Oncology

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