NDLI: The Effect of Particle Size on Some In-Vitro and In-Vivo Properties of Indomethacin-Polyethylene Glycol 6000 Solid Dispersions

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The Effect of Particle Size on Some In-Vitro and In-Vivo Properties of Indomethacin-Polyethylene Glycol 6000 Solid Dispersions

Content Provider	Scilit
Author	Ford, James L. Elliott, Peter N. C.
Copyright Year	1985
Description	Journal: Drug Development and Industrial Pharmacy Drug release from indomethacin-polyethylene glycol solid dispersions has been examined using three different size fractions. Release rates at a stirring rate of 100 rpm were generally higher from the 250-375 micron fraction than from particles in the ranges 125-188 and 500-750 microns. Release rates were highest from dispersions containing 5% indomethacin and showed a 240-fold increase at 100 rpm and a 1200-fold increase at 50 rpm over those at the same stirring rate of indomethacin alone (125-188 microns). As the percentage of indomethacin in the dispersions increased (5 to 40%) the dissolution rates decreased and for dispersions containing .15% indomethacin, complete solution of the drug was not achieved within 2 hours. The 500-750 micron fraction of the dispersion containing 10% indomethacin was significantly more gastro-toxic than particles of 125-188 microns.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048509056886
Ending Page	549
Page Count	13
Starting Page	537
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048509056886
Journal	Drug Development and Industrial Pharmacy
Issue Number	2-3
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	1985-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Polyethylene Glycol Particle Size Vivo Properties Indomethacin Polyethylene Solid Dispersions
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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