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What makes ribosomes tick?
| Content Provider | Scilit |
|---|---|
| Author | Mills, Sarah Catherine Enganti, Ramya Arnim, Albrecht G. Von |
| Copyright Year | 2017 |
| Description | Journal: RNA Biology In most organisms, gene expression over the course of the day is under the control of the circadian clock. The canonical clock operates as a gene expression circuit that is controlled at the level of transcription, and transcriptional control is also a major clock output. However, rhythmic transcription cannot explain all the observed rhythms in protein accumulation. Although it is clear that rhythmic gene expression also involves RNA processing and protein turnover, until two years ago little was known in any eukaryote about diel dynamics of mRNA translation into protein. A recent series of studies in animals and plants demonstrated that diel cycles of translation efficiency are widespread across the tree of life and its transcriptomes. There are surprising parallels between the patterns of diel translation in mammals and plants. For example, ribosomal proteins and mitochondrial proteins are under translational control in mouse liver, human tissue culture, and Arabidopsis seedlings. In contrast, the way in which the circadian clock, light-dark changes, and other environmental factors such as nutritional signals interact to drive the cycles of translation may differ between organisms. Further investigation is needed to identify the signaling pathways, biochemical mechanisms, RNA sequence features, and the physiological implications of diel translation. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/15476286.2017.1391444?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785988/pdf |
| Ending Page | 54 |
| Page Count | 11 |
| Starting Page | 44 |
| ISSN | 15476286 |
| e-ISSN | 15558584 |
| DOI | 10.1080/15476286.2017.1391444 |
| Journal | RNA Biology |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-11-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: RNA Biology Protein Synthesis Rna, Circadian Clock Diurnal Cycle |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
