NDLI: Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis

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Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis

Content Provider	Scilit
Author	Court, Colin M. Ankeny, Jacob S. Hou, Shuang Tseng, Hsian-Rong Tomlinson, James S.
Copyright Year	2015
Description	Journal: Expert Review of Molecular Diagnostics Pancreatic cancer (PC) is the fourth most common cause of cancer-related death in the USA, primarily due to late presentation coupled with an aggressive biology. The lack of adequate biomarkers for diagnosis and staging confound clinical decision-making and delay potentially effective therapies. Circulating tumor cells (CTCs) are a promising new biomarker in PC. Preliminary studies have demonstrated their potential clinical utility, and newer CTC isolation platforms have the potential to provide clinicians access to tumor tissue in a reliable, real-time manner. Such a 'liquid biopsy' has been demonstrated in several cancers, and small studies have demonstrated its potential applications in PC. This article reviews the available literature on CTCs as a biomarker in PC and presents the latest innovations in CTC research as well as their potential applications in PC.
Related Links	http://europepmc.org/articles/pmc4893319?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893319/pdf
Ending Page	1504
Page Count	14
Starting Page	1491
ISSN	14737159
e-ISSN	17448352
DOI	10.1586/14737159.2015.1091311
Journal	Expert Review of Molecular Diagnostics
Issue Number	11
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-09-21
Access Restriction	Open
Subject Keyword	Journal: Expert Review of Molecular Diagnostics Gastroenterology and Hepatology Circulating Tumor Cells Liquid Biopsy Pancreatic Cancer Personalized Medicine Precision Medicine Single Cell Sequencing
Content Type	Text
Subject	Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine

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