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Prognostic Significance of TGF-α Expression in Breast Cancer
| Content Provider | Scilit |
|---|---|
| Author | Auvinen, Päivi K. Lipponen, Pertti K. Kataja, Vesa Johansson, Risto T. Syrjänen, Kari J. |
| Copyright Year | 1996 |
| Description | Journal: Acta Oncologica A series of breast cancer biopsies from 204 women were analysed immunohistochemically for the expression of transforming growth factor alpha (TGF-alpha). Expression of TGF-alpha was intense in 119 cases (58%), weak in 63 (31%), and totally absent in 22 (11%) of the cases. No correlation was observed between the expression of TGF-alpha and tumour size, metastasis at diagnosis, histological type and grade, ER and PR status, DNA index, S-phase fraction or the expression of TGF-beta1 or beta2. However, the expression of TGF-alpha was significantly related to axillary lymph node metastasis and to low survival probability during the follow-up. These data support the earlier observations on the in vitro studies, suggesting that TGF-alpha most probably exerts an in vivo growth stimulation of female breast cancer cells. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/02841869609100717?needAccess=true http://www.tandfonline.com/doi/pdf/10.3109/02841869609100717 |
| Ending Page | 998 |
| Page Count | 4 |
| Starting Page | 995 |
| ISSN | 0284186X |
| e-ISSN | 1651226X |
| DOI | 10.3109/02841869609100717 |
| Journal | Acta Oncologica |
| Issue Number | 8 |
| Volume Number | 35 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1996-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oncologica Breast Cancer Expression of Tgf |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Hematology Oncology |
