NDLI: In Vitro Release of Hydrochlorothiazide from Capsule Formulations

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In Vitro Release of Hydrochlorothiazide from Capsule Formulations

Content Provider	Scilit
Author	Shah, Kirit A. Warren, James W. Onwuelezi, Godwin Benmaman, Joseph D. Monk, Clayborne M.
Copyright Year	1981
Description	Journal: Drug Development and Industrial Pharmacy Five different hydrochlorothiazide (50mg. per capsule) capsule formulations were prepared with one of the following diluents: corn starch, dibasic calcium phosphate, lactose, microcrystalllne cellulose, or sodium carboxymethyl starch. A comparative dissolution study was conducted using the USP procedure. Significant differences (p = 0.05) were found among the formulations relative to in vitro dissolution rates over a two-hour sampling period. The formulations prepared with lactose consistently ranked near the top (Newman-Keuls multiple range test) while the formulation prepared with sodium carboxymethyl starch ranked last at each sampling time except 3 min.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048109055692
Ending Page	691
Page Count	9
Starting Page	683
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048109055692
Journal	Drug Development and Industrial Pharmacy
Issue Number	6
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	1981-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Capsule Formulations Hydrochlorothiazide From Capsule Vitro Release of Hydrochlorothiazide
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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