NDLI: Timing of human chorionic gonadotropin (hCG) hormone administration in IVF/ICSI protocols using GnRH agonist or antagonists: a systematic review and meta-analysis

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Timing of human chorionic gonadotropin (hCG) hormone administration in IVF/ICSI protocols using GnRH agonist or antagonists: a systematic review and meta-analysis

Content Provider	Scilit
Author	Chen, Ying Zhang, Yi Hu, Min Liu, Xiru Qi, Hongbo
Copyright Year	2014
Description	Journal: Gynecological Endocrinology Objective: To evaluate the effect of altering the timing of human chorionic gonadotropin (hCG) administration on the clinical outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) using gonadotropic hormone releasing hormone (GnRH) agonist or antagonist. Methods: We systematically searched six databases. Randomized controlled trials (RCTs) of the effects of altering the timing of hCG administration on the clinical outcome of IVF and ICSI using GnRH agonist or antagonist were included. A meta-analysis was conducted following a quality evaluation performed with Cochrane Collaboration's Review Manager (RevMan) 5.0.2. Results: Seven RCTs and a total of 1295 participants were included. Significant difference was observed regarding estradiol and progesterone levels on the day of hCG administration and oocyte retrieval between early hCG and late hCG administration group and in favor of the latter. The fertilization rate was not statistically different between early and 24-h late hCG groups, but it is significantly higher in the 48-h late hCG group. The pooled results showed no significant differences in the ongoing pregnancy rate per oocyte pick-up, the miscarriage rate and the live birth rate. Conclusion: The prolongation of follicular phase by delaying hCG administration could increase estradiol, progesterone levels and oocyte retrieval, which will not influence ongoing pregnancy rate per oocyte pick-up, miscarriage rate and live birth rate. Postponing hCG may enable increased flexibility of cycle scheduling to avoid weekend procedures.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/09513590.2014.895984
Ending Page	437
Page Count	7
Starting Page	431
ISSN	09513590
e-ISSN	14730766
DOI	10.3109/09513590.2014.895984
Journal	Gynecological Endocrinology
Issue Number	6
Volume Number	30
Language	English
Publisher	Informa UK Limited
Publisher Date	2014-06-01
Access Restriction	Open
Subject Keyword	Journal: Gynecological Endocrinology Gnrh Agonist Gnrh Antagonist in Vitro Fertilization Intracytoplasmic Sperm Injection Meta-analysis Oocyte Retrieval Systematic Review
Content Type	Text
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Obstetrics and Gynecology

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