NDLI: Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

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Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

Content Provider	Scilit
Author	Lin, Jeng-Yee Tsai, Feng-Chou Wallace, Christopher Glenn Huang, Wei-Chao Wei, Fu-Chan Liao, Shuen-Kuei
Copyright Year	2013
Description	Journal: Chimerism We demonstrate herein that combination treatment with regulatory T cells (Tregs) and vascularized bone marrow transplantation (VBMT) can achieve stable mixed chimerism and long-term transplantation tolerance to vascularized composite allografts (VCA) without requiring cytoreductive recipient conditioning in rats. An appreciable number of Tregs of recipient origin was shown at the interface between recipient and transplanted VCA tissues, implicating a significant role for Tregs in protecting VCA from rejection. This cytoreduction-free protocol using co-treatment with Tregs and VBMT warrants further investigation toward potential clinical application for VCA transplantation.
Related Links	http://europepmc.org/articles/pmc3654733?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654733/pdf https://www.landesbioscience.com/journals/chimerism/2012CHIMERISM0105R.pdf
Ending Page	22
Page Count	3
Starting Page	20
ISSN	19381956
e-ISSN	19381964
DOI	10.4161/chim.23349
Journal	Chimerism
Issue Number	1
Volume Number	4
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-01-01
Access Restriction	Open
Subject Keyword	Journal: Chimerism Research and Experimental Medicine Composite Tissue Allograft Graft-versus-host Disease Mixed Chimerism Transplantation Vascularized Bone Marrow Transplantation Vascularized Composite Allograft
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry 1300/1301

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