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Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan
| Content Provider | Scilit |
|---|---|
| Author | Mahlich, Jörg Sruamsiri, Rosarin |
| Copyright Year | 2016 |
| Description | Journal: Patient preference and adherence Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan Jörg Mahlich,1,2 Rosarin Sruamsiri1,3 1Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics (DICE), University of Düsseldorf, Düsseldorf, Germany; 3Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand Background: To assess persistence rates of biologic agents for the treatment of rheumatoid arthritis in Japan.Methods: Based on Japanese claims data of 16,214 patients between 2012 and 2014, 6-, 12-, and 18-month persistence rates of different biologic agents were calculated. Determinants of persistence were assessed by means of a multivariate Cox proportional hazard model controlling for age, sex, and comorbidities. A sensitivity analysis was performed with different definitions of persistence and parametric survival analysis.Results: Overall persistence rates in Japan are high and reach 86% after 1 year in the entire sample. The persistence rate for the biologic-naïve subpopulation is above 95%. Persistence is higher for older patients (hazard ratio 0.60 [95% confidence interval 0.40–0.91] for >75 years compared to ≤60 years) and lower for patients with a high comorbidity score (hazard ratio 1.33; 95% confidence interval 1.03–1.70 for Charlson Comorbidity Index score 3–5 compared to ≤2). We found a high variation of persistence between different drugs.Conclusion: Japanese rheumatoid arthritis patients have a high persistence rate of biologic treatments. However, multiple factors affect the persistence rate of Japanese patients, including age, comorbidities, and patient type. Naïve patients tend to have a higher persistence rate than continuing biologic patients. Keywords: Japan, rheumatoid arthritis, database analysis, persistence, biologics |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981174/pdf https://www.dovepress.com/getfile.php?fileID=31749 |
| Ending Page | 1519 |
| Page Count | 11 |
| Starting Page | 1509 |
| ISSN | 1177889X |
| DOI | 10.2147/ppa.s110147 |
| Journal | Patient preference and adherence |
| Volume Number | ume 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Patient preference and adherence Rheumatology Database Analysis Rheumatoid Arthritis |
| Content Type | Text |
| Subject | Social Sciences Pharmacology, Toxicology and Pharmaceutics Health Policy |
