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DNA methylation as a universal biomarker
| Content Provider | Scilit |
|---|---|
| Author | Levenson, Victor V. |
| Copyright Year | 2010 |
| Description | Journal: Expert Review of Molecular Diagnostics Cell-free circulating DNA carries not only tumor-specific changes in its sequence but also distinctive epigenetic marks, namely DNA methylation, in certain GC-rich fragments. These fragments are usually located within the promoters and first exons of many genes, comprising CpG islands. Analysis of DNA methylation using cell-free circulating DNA can facilitate development of very accurate biomarkers for detection, diagnosis, prediction of response to therapy and prognosis of outcomes. Recent data suggest that benign and inflammatory diseases have very specific methylation patterns within cell-free circulating DNA, which are different from the pattern of a malignant tumor of the same organ. In addition, specific methylation patterns have been detected for cancers of different organs, so a differential diagnosis of site-specific cancer appears feasible. Currently, cancer-related applications dominate the field, although methylation-based biomarkers may also be possible for other diseases, including neurodegenerative and psychiatric disorders. |
| Related Links | http://europepmc.org/articles/pmc2933138?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933138/pdf |
| Ending Page | 488 |
| Page Count | 8 |
| Starting Page | 481 |
| ISSN | 14737159 |
| e-ISSN | 17448352 |
| DOI | 10.1586/erm.10.17 |
| Journal | Expert Review of Molecular Diagnostics |
| Issue Number | 4 |
| Volume Number | 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Expert Review of Molecular Diagnostics Medical Laboratory Technology Cell-free Plasma Dna |
| Content Type | Text |
| Subject | Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine |
