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Brain Metastases — Comparison of Gadodiamide Injection-Enhanced MR Imaging at Standard and High Dose, Contrast-Enhanced CT and Non-Contrast-Enhanced MR Imaging
| Content Provider | Scilit |
|---|---|
| Author | Åkeson, Per Larsson, E. -M. Kristoffersen, D. T. Jonsson, E. Holtås, S. |
| Copyright Year | 1995 |
| Description | Journal: Acta Radiologica The aim was to compare the abilities of contrast-enhanced CT, non-contrast-enhanced MR imaging and contrast-enhanced MR imaging using standard (0.1 mmol/kg b.w.) and high (0.3 mmol/kg b.w.) doses of Gadodiamide injection to detect brain metastases (i.e. blood-brain barrier damage). Sixteen patients with at least 2 metastases found by CT were evaluated by MR imaging using non-contrast-enhanced spin-echo, T1-weighted, T2-weighted sequences, and contrast-enhanced spin-echo T1-weighted sequences at 2 dose levels. Gadodiamide injection was first given at the dose of 0.1 mmol/kg b.w. After imaging, another 0.2 mmol/kg b.w. was given, yielding a cumulative dose of 0.3 mmol/kg b.w. No contrast media-related adverse events were recorded. The images were evaluated openly by one and blindly by 2 investigators and the number of metastases, size, delineation (open study) and diagnostic certainty (blind study) of each individual metastasis noted. High-dose MR imaging showed significantly more and smaller metastases than any other examination, and gave a higher diagnostic certainty. All high-dose images were superior to those with the standard dose MR imaging when compared blindly in pairs. We conclude that spin-echo MR imaging with a high dose of Gadodiamide injection is an efficient way to improve the detection of brain metastases, in particular of small ones. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/02841859509177639 |
| Ending Page | 306 |
| Page Count | 7 |
| Starting Page | 300 |
| ISSN | 02841851 |
| e-ISSN | 16000455 |
| DOI | 10.3109/02841859509177639 |
| Journal | Acta Radiologica |
| Issue Number | 3 |
| Volume Number | 36 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1995-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Radiologica Radiology, Nuclear Medicine and Imaging Brain Neoplasms —, Secondary Contrast Media, Enhancement —, Gadolinium |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
