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Cyclophosphamide loaded albumin microspheres II. Release characteristics
| Content Provider | Scilit |
|---|---|
| Author | Vural, I. Kasl, H. S. Hincal, A. A. Cave, G. |
| Copyright Year | 1990 |
| Description | Journal: Journal of Microencapsulation The purpose of this investigation was to evaluate the release characteristics of cyclophosphamide (CP) from glutaraldehyde stabilized human serum albumin microspheres, and to study the effect of the extent of cross-linking, the amount of the stabilizing agent and the size of the microspheres on the in vitro release of CP. Microspheres were prepared by emulsion polymerization method using two different volumes (0.1 and 0.7 ml) of glutaraldehyde solution (25 per cent) and two different crosslinking durations (15 min and 1 h). The resulting mean particle size of the microspheres also varied between 2.5 microns and 3.7 microns. The total CP content in microspheres was analysed from the surface drug and the entrapped drug. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/02652049009040474 |
| Ending Page | 516 |
| Page Count | 6 |
| Starting Page | 511 |
| ISSN | 02652048 |
| e-ISSN | 14645246 |
| DOI | 10.3109/02652049009040474 |
| Journal | Journal of Microencapsulation |
| Issue Number | 4 |
| Volume Number | 7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1990-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Microencapsulation Pharmacology and Pharmacy Cyclophosphamide Release Characteristics Particle Size Albumin Microspheres Glutaraldehyde Polymerization Loaded Albumin |
| Content Type | Text |
| Subject | Organic Chemistry Colloid and Surface Chemistry Physical and Theoretical Chemistry Bioengineering Pharmaceutical Science |
