NDLI: Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils

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Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils

Content Provider	Scilit
Author	Poirier, Michelle Simard, Jean-Christophe Girard, Denis
Copyright Year	2015
Description	Journal: Journal of immunotoxicology The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell biology is poorly documented. In the study here, it was decided to determine if AgNP with a diameter of 70 nm $(AgNP_{70}$) will alter the biology of human PMN similarly to $AgNP_{20}$ previously reported to induce apoptosis and inhibit de novo protein synthesis. The results here indicated that, in contrast to $AgNP_{20}$, $AgNP_{70}$ delayed PMN apoptosis. However, both $AgNP_{20}$ and $AgNP_{70}$ inhibited de novo protein synthesis. Both forms of AgNP did not significantly increase reactive oxygen species (ROS) production, but $AgNP_{20}$ significantly increased the cell production of the CXCL8 chemokine (IL-8). In addition, $AgNP_{20}$, but not $AgNP_{70}$, induced the release of albumin and matrix metalloproteinase-9 (MMP-9/gelatinase B) into culture supernatants. Consistent with this latter observation, gelatinase activity was increased by $AgNP_{20}$, as assessed by zymography. From these outcomes, it is concluded that two NP with different initial diameters can possess similar – as well as distinct – biological properties in modulating human PMN functions. These outcomes are testimony to the complexity of the modes of action of NP at the cellular level.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/1547691X.2015.1106622?needAccess=true https://www.tandfonline.com/doi/pdf/10.3109/1547691X.2015.1106622
Ending Page	385
Page Count	11
Starting Page	375
ISSN	1547691X
e-ISSN	15476901
DOI	10.3109/1547691x.2015.1106622
Journal	Journal of immunotoxicology
Issue Number	3
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-05-03
Access Restriction	Open
Subject Keyword	Journal: Journal of immunotoxicology Inflammation Nanotoxicology
Content Type	Text
Subject	Toxicology Immunology

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