Loading...
Please wait, while we are loading the content...
Similar Documents
Captan Metabolism in Humans Yields two Biomarkers, Tetrahydrophthalimide (THPI) and Thiazolidine-2-Thione-4-Carboxylic Acid (TTCA) in Urine
| Content Provider | Scilit |
|---|---|
| Author | Krieger, Robert I. Thongsinthusak, Tian |
| Copyright Year | 1993 |
| Description | Journal: Drug and Chemical Toxicology Captan fungicide (N-(trichloromethylthio)-4-cyclohexene-1,2-dicarboximide) metabolism in two human volunteers rapidly yields THPI (tetrahydrophthalimide) and TTCA (thiazolidine-2-thione-4-carboxylic acid). The work was done to evaluate usefulness of TTCA and THPI as biomarkers of occupational exposure and to compare human and rat dermal absorption and metabolism. THPI in 12h urine ranged from MDL (5 ppb) to 640 ppb and was stable for at least one year. TTCA was also a stable metabolite, but the MDL was 50 ppb. THPI was detectable in urine for 7 2 hours following oral dosages of 1 mg/kg, but most was eliminated 0–24 h. No THPI was detectable in urine following application of a chloroform solution to hands, forearms, or inguinal region. Dermal absorption and metabolism of captan are substantially different in humans and rats. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/01480549309031997 |
| Ending Page | 225 |
| Page Count | 19 |
| Starting Page | 207 |
| ISSN | 01480545 |
| e-ISSN | 15256014 |
| DOI | 10.3109/01480549309031997 |
| Journal | Drug and Chemical Toxicology |
| Issue Number | 2 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug and Chemical Toxicology Dermal Absorption Carboxylic Acid Tetrahydrophthalimide Thiazolidine |
| Content Type | Text |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
