NDLI: CSF-Neuropeptides in schizophrenia

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CSF-Neuropeptides in schizophrenia

Content Provider	Scilit
Author	Lindström, Leif H.
Copyright Year	1985
Description	Journal: Nordisk Psykiatrisk Tidsskrift The concentrations of the neuropeptides Fraction I endorphins, neurotensin, delta-sleep inducing-peptide (DSIP) and neuropeptide Y (NPY) as well as the amine metabolites homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) from schizophrenic patients and healthy volunteers. A significant increase of receptor active Fraction I endorphins were found in the patient group compared to controls. The increased levels were correlated to low levels of HVA indicating a relationship between central nervous opioid and dopamine activity in schizophrenia. The CSF-levels of neurotensin showed a bimodal distribution with low levels in a subpopulation of the schizophrenic patients. The decreased levels showed a tendency towards normalization during neuroleptic treatment. Significantly lower concentrations of DSIP were seen in schizophrenics with no changes after treatment with neuroleptics. In contrast, the CSF-levels of NPY did not differ between patients and controls but a significant correlation was found between NPY and HVA and 5-HIAA respectively, both in schizophrenics and controls. The findings indicate abnormal synthesis, release or degradation of the neuropeptides Fraction I endorphins, neurotensin and DSIP in the central nervous system in subgroups of schizophrenic patients. Schizophrenia, CSF, homovanillic acid, delta sleep-inducing peptide (DSIP), endorphins, neurotensin.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08039488509101957
Ending Page	55
Page Count	5
Starting Page	51
ISSN	00291455
DOI	10.3109/08039488509101957
Journal	Nordisk Psykiatrisk Tidsskrift
Issue Number	sup11
Volume Number	39
Language	English
Publisher	Informa UK Limited
Publisher Date	1985-01-01
Access Restriction	Open
Subject Keyword	Journal: Nordisk Psykiatrisk Tidsskrift Medical Laboratory Technology Csf Neuropeptides in Schizophrenia
Content Type	Text
Subject	Psychiatry and Mental Health

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