Loading...
Please wait, while we are loading the content...
Similar Documents
Warfarin treatment and risk of stroke among primary care patients with atrial fibrillation
| Content Provider | Scilit |
|---|---|
| Author | Wändell, Per Carlsson, Axel C. Holzmann, Martin J. Ärnlöv, Johan Johansson, Sven-Erik Sundquist, Jan Sundquist, Kristina |
| Copyright Year | 2016 |
| Description | Journal: Scandinavian Cardiovascular Journal Objective. Our aim was to study the risk of a first ischaemic stroke (IS) in patients with atrial fibrillation (AF) treated in primary healthcare. Design. The study population included all adults (n = 11,517), 45 years and older diagnosed with AF, from 75 primary care centres in Sweden between 2001 and 2007. IS was defined as a hospital care event of stroke between 2001 and 2010. Association between incident stroke and warfarin treatment was explored using Cox regression analysis, with hazard ratios (HRs), and 95% confidence intervals (95%CIs). Adjustment was made for age, socioeconomic factors and co-morbidity. Results. Persistent treatment with warfarin was present among 33.7% of women and 40.0% among men. Persistent warfarin treatment, compared to no persistent treatment, was associated with a stroke preventing effect with fully adjusted HRs of 0.25 (95%CI 0.18–0.36) in women, and 0.25 (95%CI 0.19–0.32) in men. A $CHA_{2}DS_{2}$-VASc score of at least two among women, and three among men, was associated with a stroke risk exceeding 18% during a mean follow-up of 5.4 years. Risk of haemorrhagic stroke was not increased. Conclusions. Warfarin is effective in preventing stroke in AF patients in primary healthcare. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152680/pdf |
| Ending Page | 316 |
| Page Count | 6 |
| Starting Page | 311 |
| ISSN | 14017431 |
| e-ISSN | 16512006 |
| DOI | 10.1080/14017431.2016.1215519 |
| Journal | Scandinavian Cardiovascular Journal |
| Issue Number | 5-6 |
| Volume Number | 50 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Cardiovascular Journal Primary Health Care Atrial Fibrillation Ischemic Stroke Co-morbidity Anticoagulant |
| Content Type | Text |
| Subject | Cardiology and Cardiovascular Medicine |
