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Salt Sensitivity in Hypertensive Type-1 Diabetes Mellitus
| Content Provider | Scilit |
|---|---|
| Author | Gerdts, E. Svarstad, E. Myking, O. L. Lund-Johansen, P. Omvik, P. |
| Copyright Year | 1996 |
| Description | Journal: Blood Pressure Gerdts E, Svarstad E, Myking OL, Lund-Johansen P, and Omvik P. Salt sensitivity in hypertensive type-I diabetes mellitus. As sodium retention has been proposed as a causal factor in the development of hypertension in diabetic patients, a high incidence of salt sensitivity has been suggested. To evaluate the influence of dietary sodium intake on blood pressure, casual and 24-h blood pressure was measured in 30 hypertensive type-I diabetic patients aged 24-67 (mean 46) years while they were on habitual diet, after 6 days of low-sodium diet (50 mmol/day), and after 6 days of high-sodium diet (250mmol/day). Nine patients (30%) who increased their 24-h mean blood pressure by more than 10% when going from low- to high-sodium intake were classified as salt sensitive; the others as salt resistant. The salt sensitive group had a significantly lower urinary excretion of dopamine at baseline, and a higher diuresis and a more pronounced decrease in 24-h blood pressure during salt depletion (all p < 0.01). Low-sodium diet reduced casual and 24-h blood pressure by 4% in the total study population compared with 9% in the salt sensitive group (p < 0.01). There was no difference in glomerular filtration rate, filtration fraction, proteinuria or urinary sodium excretion between the groups. Conclusions: Sodium restriction more effectively reduces blood pressure in the salt sensitive minority of hypertensive type-1 diabetic patients irrespective of renal function. The incidence of salt sensitivity is not increased in hypertensive type-I diabetic patients compared with essential hypertensive patients. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/08037059609062112 |
| Ending Page | 85 |
| Page Count | 8 |
| Starting Page | 78 |
| ISSN | 08037051 |
| e-ISSN | 16511999 |
| DOI | 10.3109/08037059609062112 |
| Journal | Blood Pressure |
| Issue Number | 2 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1996-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Blood Pressure Peripheral Vascular Disease Ambulatory Blood Pressure |
| Content Type | Text |
| Subject | Internal Medicine Cardiology and Cardiovascular Medicine |
