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Platelet Count within the Normal Range at Hospital Admission is Associated with Mortality in Patients with Community-Acquired Pneumonia
| Content Provider | Scilit |
|---|---|
| Author | Moulis, Guillaume Christiansen, Christian Fynbo Darvalics, Bianka Andersen, Ina Trolle Nørgaard, Mette |
| Copyright Year | 2020 |
| Description | Journal: Clinical epidemiology Background: Apart from their hemostatic role, platelets are immune cells that play a role in fighting infections. The presence of thrombocytopenia and thrombocytosis at hospital admission are predictors of mortality in community-acquired pneumonia patients. We hypothesized that variations in platelet counts within the normal range also may be associated with mortality in these patients. Methods: The study included all adults in the North and Central Denmark Regions with a first acute hospital admission for community-acquired pneumonia during 2006– 2012. We assessed the association between the first platelet count within ± 24 hours of admission (within the normal range of 150 to 400 x $10^{9}$/L) and 30-day mortality using Cox models. Analyses were adjusted for age, sex, Charlson Comorbidity Index score, hemoglobin level, leukocyte count, and creatinine level at admission. Results: Among the 12,905 study patients, 30-day mortality was 12.4%. The mean platelet count upon admission was 250 × $10^{9}$/L. Compared with the 250– 275 × $10^{9}$/L category, platelet counts of 151– 175 were associated with a lower 30-day mortality (adjusted hazard ratio [aHR]: 0.79, 95% confidence interval [CI]: 0.63– 0.99), while higher platelet counts were associated with a higher 30-day mortality (351– 375 × $10^{9}$/L, aHR: 1.34, 95% CI: 1.07– 1.68; 376– 400× $10^{9}$/L, aHR: 1.21, 95% CI: 0.94– 1.56). Conclusion: Platelet counts, even within the normal range, are associated with mortality in adult patients hospitalized for community-acquired pneumonia. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369307/pdf https://www.dovepress.com/getfile.php?fileID=59511 |
| Ending Page | 716 |
| Page Count | 6 |
| Starting Page | 711 |
| ISSN | 11791349 |
| e-ISSN | 11791349 |
| DOI | 10.2147/clep.s245067 |
| Journal | Clinical epidemiology |
| Volume Number | ume 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical epidemiology Respiratory System Community-acquired Pneumonia Platelet Count Thrombocytopenia Thrombocytosis |
| Content Type | Text |
| Subject | Epidemiology |
