NDLI: Sarecycline: A Review of Preclinical and Clinical Evidence

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Sarecycline: A Review of Preclinical and Clinical Evidence

Content Provider	Scilit
Author	Moore, Angela Yen Rosso, James Del Johnson, Jodi L. Grada, Ayman
Copyright Year	2020
Description	Journal: Clinical, Cosmetic and Investigational Dermatology Sarecycline is a tetracycline-derived oral antibiotic, specifically designed for acne, and is approved by the Food and Drug Administration (FDA) in 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris (AV) in patients 9 years of age and older. It has been decades since a novel systemic antibiotic was approved to treat AV, a disease that affects up to 90% of teenagers and young adults worldwide and lasts well into adulthood. Sarecycline holds promise to yield fewer side effects than other commonly used broad-spectrum tetracyclines, including minocycline and doxycycline. The narrower spectrum of antibacterial activity of sarecycline, which specifically targets C. acnes and some Gram-positive bacteria with little or no activity against Gram-negative bacteria, suggests not only the potential for reduced emergence of antibiotic-resistant bacterial strains but also less disruption of the human gut microflora. Here, we review the key preclinical and clinical evidence on sarecycline.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431453/pdf https://www.dovepress.com/getfile.php?fileID=60620
Ending Page	560
Page Count	8
Starting Page	553
ISSN	11787015
DOI	10.2147/ccid.s190473
Journal	Clinical, Cosmetic and Investigational Dermatology
Volume Number	ume 13
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-08-01
Access Restriction	Open
Subject Keyword	Journal: Clinical, Cosmetic and Investigational Dermatology Acne Vulgaris Narrow Spectrum Tetracycline
Content Type	Text
Subject	Dermatology

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