Relationship between Antigen Levels in Middle Ear and Antigen Passage through Round Window Membrane in Antigen-induced Otitis Media

Content Provider	Scilit
Author	Hamaguchi, Yukiyoshi Juhn, Steven K. Morizono, Tetsuo
Copyright Year	1988
Description	Journal: Acta Oto-Laryngologica By using an antigen-induced (Arthus) otitis media (OM) model in chinchillas sensitized with human serum albumin (HSA), we investigated the passage of HSA through the round window membrane (RWM) by measuring HSA levels in both the middle ear fluid (MEF) and the perilymph (PL). The effect of corticosteroid treatment on HSA passage was also studied. Mean HSA levels in both the MEF and the PL were proportional to the HSA dose administered (0.5, 5, 50 mg/ml). The proportion of HSA-positive PL samples was significantly lower in the sensitized group than that of the control (p<0.01). HSA levels in the PL appear to depend on HSA levels in the MEF, which were significantly depressed in the sensitized animals. These results suggest that an immunological reaction may be involved in the reduction of antigen (HSA) passage through the RWM by reducing antigen concentrations in the MEF Corticosteroid treatment reduces the passage of HSA into the PL in non-sensitized animals.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00016488809138894
Ending Page	128
Page Count	5
Starting Page	124
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016488809138894
Journal	Acta Oto-Laryngologica
Issue Number	sup457
Volume Number	105
Language	English
Publisher	Informa UK Limited
Publisher Date	1988-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-Laryngologica Otorhinolaryngology Otitis Media Round Window Antigen Passage Antigen Induced Induced Otitis Window Membrane Antigen Levels
Content Type	Text
Subject	Otorhinolaryngology