NDLI: Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemia

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Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemia

Content Provider	Scilit
Author	Bianchi, Sergio Moreno, Pilar Landoni, Ana Inés Naya, Hugo Oppezzo, Pablo Dighiero, Guillermo Gabus, Raul Pritsch, Otto
Copyright Year	2010
Description	Journal: Leukemia & Lymphoma B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of long-lived circulating clonal leukemic B-cells, although the etiopathogenesis remains unclear. The incidence of CLL is variable in different regions around the world. While it is the most frequent chronic leukemia in Western countries, it has a low incidence in Asia. In this work we have investigated the immunoglobulin heavy chain gene rearrangements and mutational status in 80 Uruguayan patients with CLL, and compared these results with those obtained in other geographic regions. Our results demonstrate that Uruguayan patients with CLL display an IGHV gene usage which resembles that observed in Mediterranean countries and exhibits certain differences compared with Brazilian and Asian series, as expected, considering the ethnic basis of the Uruguayan population. This suggests that genetic influences could be important in the development and etiopathogenesis of CLL, but larger studies are necessary to substantiate this possibility.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/10428194.2010.522283
Ending Page	2078
Page Count	9
Starting Page	2070
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2010.522283
Journal	Leukemia & Lymphoma
Issue Number	11
Volume Number	51
Language	English
Publisher	Informa UK Limited
Publisher Date	2010-10-07
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Medical Laboratory Technology Gene Rearrangement Immunoglobulin Heavy Uruguayan Patients
Content Type	Text
Subject	Hematology Cancer Research Oncology

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