NDLI: Accuracy of distortion-product otoacoustic emissions-based ototoxicity monitoring using various primary frequency step-sizes.

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Accuracy of distortion-product otoacoustic emissions-based ototoxicity monitoring using various primary frequency step-sizes.

Content Provider	Scilit
Author	McMillan, Garnett P. Konrad-Martin, Dawn Dille, Marilyn F.
Copyright Year	2012
Description	Journal: International Journal of Audiology Objective: A cisplatin ototoxicity monitoring protocol was recently proposed using distortion-product otoacoustic emissions (DPOAEs) measured in 1/48th octave steps over the highest obtainable quarter octave (). This protocol can take up to 40 minutes to complete in both ears among seriously ill patients in a potentially noisy test environment. The goal of the current study was to contrast the diagnostic accuracy of ototoxicity monitoring protocols based on changes in DPOAE levels at wider, more rapidly tested, primary frequency step sizes. Design: Measure DPOAE levels in 1/48th octave steps over the highest half-octave of obtainable DPOAEs prior to treatment and at each ototoxicity monitoring session during the course of treatment with cisplatin. Study sample: Nineteen cancer patients being treated with cisplatin at the Portland Veterans Affairs Medical Center were observed over 56 monitoring appointments. Hearing thresholds in the sensitive region for ototoxicity (SRO) were measured concurrently with DPOAE levels. Results: DPOAE levels measured in 1/24th octave steps provided comparable accuracy, and half the testing time, to the 1/48th octave step protocol previously described. Conclusions: DPOAE level shifts measured in 1/24th octave steps may provide a basis for rapid ototoxicity monitoring among adult cancer patients treated with cisplatin.
Related Links	http://europepmc.org/articles/pmc5549624?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549624/pdf
ISSN	14992027
e-ISSN	17088186
DOI	10.3109/14992027.2012.688143
Journal	International Journal of Audiology
Issue Number	9
Volume Number	51
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-05-10
Access Restriction	Open
Subject Keyword	Journal: International Journal of Audiology Otorhinolaryngology Distortion-product Otoacoustic Emissions Ototoxicity Monitoring Fine Structure
Content Type	Text
Subject	Speech and Hearing Linguistics and Language

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