NDLI: Evaluation of Xanthan Gum in the Preparation of Sustained Release Matrix Tablets

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Evaluation of Xanthan Gum in the Preparation of Sustained Release Matrix Tablets

Content Provider	Scilit
Author	Dhopeshwarkar, Vinny Zatz, Joel L.
Copyright Year	1993
Description	Journal: Drug Development and Industrial Pharmacy The objective of this study was to evaluate xanthan gum as a matrix former for the preparation of sustained release tablets. Preliminary experiments indicated that a fine particle sue of xanthan gum produced the slowest and most reproducible release profiles. Based on single surface experiments and tablet erosion studies, it was concluded that release of a soluble drug (chlorpheniramine maleate) and an insoluble drug (theophylline) from tablets containing low concentraions of xanthan gum was mainly via diffusion and erosion, respectively. Drug release from tablets containing xanthan gum was slightly faster in acidic media due to more rapid initial surface erosion than at higher pH. After hydration of the gum, drug release was essentially pH-independent. The amount released was directly proportional to the loading dose of drug and inversely proportional to gum concentration in tablets. Release profiles of chlorpheniramine maleate and theophylline remained unchanged after three months storage of the tablets at 40°C/80% RH and 40°C. Model tablets containing 5% xanthan gum exhibited release profiles similar to tablets containing 15% hydroxypropyl methylcellulose.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049309062997
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049309062997
Journal	Drug Development and Industrial Pharmacy
Issue Number	9
Volume Number	19
Language	English
Publisher	Informa UK Limited
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Matrix Tablets Release Matrix Sustained Release
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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