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A surprise cell of origin for Barrett’s esophagus
| Content Provider | Scilit |
|---|---|
| Author | von Holzen, Urs Enders, Greg H. |
| Copyright Year | 2012 |
| Description | Journal: Cancer Biology & Therapy Barrett's esophagus is a metaplasia of the distal esophagus that is the only recognized precursor of esophageal adenocarcinoma. Despite a characteristic histology, the pathogenesis of Barrett's has remained obscure. A recent paper from the laboratories of Wa Xian and Frank McKeon presents evidence for a novel cell of origin of Barrett's. Their work is based on studies of mice engineered to lack the squamous epithelial stem cell survival factor p63. These mice develop a metaplasia of the proximal stomach and esophagus that harbors substantial histological and molecular features of Barrett's. The metaplasia appears to form from embryonic progenitor cells that normally persists post-natally only at the squamo-columnar junction. Moreover, in their model, the metaplasia is initiated not by mutation but by reduced competition between these cells and squamous epithelial cells. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.20088?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408968/pdf |
| Ending Page | 591 |
| Page Count | 4 |
| Starting Page | 588 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.20088 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 8 |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Research and Experimental Medicine Barrett's Esophagus Epithelial Stem Cell Esophageal Adenocarcinoma Esophageal Cancer Progenitor Cell |
| Content Type | Text |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
