NDLI: Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles

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Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles

Content Provider	Scilit
Author	Wang, Junjian
Copyright Year	2020
Description	Journal: Drug design, development and therapy Purpose: Cervical cancer is one of the most common causes of death among women globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and gemcitabine are recommended as first-line therapies. Methods: This study focuses on the development of folate-decorated, pH-sensitive lipid-polymer hybrid nanoparticles (LPNs). Loading carboplatin (CBP) and paclitaxel (PTX), LPNs were expected to combine the therapeutic effects of CBP and PTX, thus show synergistic ability on cervical cancer. Results: FA-CBP/PTX-LPNs showed the sizes of 169.9 ± 5.6 nm, with a narrow size distribution of 0.151 ± 0.023. FA-CBP/PTX-LPNs exhibited pH-responsive drug release, high cellular uptake efficiency (66.7 ± 3.1%), and prominent cell inhibition capacity (23 ± 1.1%). In vivo tumor distribution and tumor inhibition efficiency of FA-CBP/PTX-LPNs was the highest, with no obvious body weight lost. Conclusion: High tumor distribution and remarkable antitumor efficiency obtained using in vitro as well as in vivo models further proved the FA-CBP/PTX-LPNs is a promising tool for cervical cancer therapy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049774/pdf https://www.dovepress.com/getfile.php?fileID=56400
Ending Page	832
Page Count	10
Starting Page	823
e-ISSN	11778881
DOI	10.2147/dddt.s235098
Journal	Drug design, development and therapy
Volume Number	ume 14
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-02-01
Access Restriction	Open
Subject Keyword	Journal: Drug design, development and therapy Cervical Cancer Lipid-polymer Hybrid Nanoparticles Ph-sensitive
Content Type	Text

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