NDLI: Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles

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Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles

Content Provider	Scilit
Author	Pala, Katarzyna Serwotka, Anna Jeleń, Filip Jakimowicz, Piotr Otlewski, Jacek
Copyright Year	2013
Description	Journal: International Journal of Nanomedicine Targeted therapy is a method owing to its limited side effect profile, particularly in cancer treatment. Magnetic hyperthermia, which is induced by nanoparticles (NPs) conjugated with targeting agents, can be useful in combination with chemo- or radiotherapy. In this paper, we constructed dextran-coated ferric oxide NPs conjugated with specific anti-human epidermal growth factor receptor (HER2) aptamer and used them to induce magnetic hyperthermia in cultured cells. The specificity of the tagged NPs was determined by studying their effect relative to that of non-tagged NPs against two cell lines: human adenocarcinoma SK-BR3, overexpressing the HER2 receptor; and U-87 MG, a human glioblastoma epithelial cell line, not expressing HER2. In order to confirm the interaction of the tagged NPs with the cells we used, fluorescence microscopy and fluorescence-activated cell sorting analysis were performed. All of these experiments showed that the aptamer-tagged NPs were highly specific toward the HER2-expressing cells. In addition, a ninetyfold lower dose of the tagged NPs relative to that of the non-tagged NPs was needed to achieve ~50% cell killing by hyperthermia of the SK-BR3 cell line, while for the U-87 MG cells the viability level was close to 100%. These results show that targeted NPs can be applied at substantially lower doses than non-targeted ones to achieve similar effects of hyperthermia, which should greatly limit the side effects of treatment.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872225/pdf https://www.dovepress.com/getfile.php?fileID=18493
Ending Page	76
Page Count	10
Starting Page	67
e-ISSN	11782013
DOI	10.2147/ijn.s52539
Journal	International Journal of Nanomedicine
Issue Number	1
Volume Number	9
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-12-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Pharmacology and Pharmacy Superparamagnetic Nanoparticles Hyperthermia Targeted Therapy
Content Type	Text

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