Loading...
Please wait, while we are loading the content...
Similar Documents
Omeprazole plus Amoxicillin for Cure of Helicobacter pylori Infection Factors Influencing the Treatment Success
| Content Provider | Scilit |
|---|---|
| Author | Labenz, J. Leverkus, F. Börsch, G. |
| Copyright Year | 1994 |
| Description | Journal: Scandinavian Journal of Gastroenterology Labenz J, Leverkus F. Börsch G. Omeprazole plus amoxicillin for cure of Helicobacter pylori infection. Factors influencing the treatment success. Scand J Gastroenterol 1994;29:1070-1075. Background: Omeprazole plus amoxicillin may cure Helicobacter pylori infection. However, the published results vary rather widely, and the factors influencing the treatment success remain unclear. Methods: Four hundred and twenty-three H. pylori-positive patients were treated with 1- or 2-week regimens comprising 411 mg or 80 mg omeprazole and amoxicillin in 11 prospective protocols. A complete set of data was available for 405 patients (ulcer disease, n = 383; dyspepsia, n = 22) and was submitted to uni- and multi-variate statistical analyses to elucidate the factors affecting the cure rates of the infection; 18 patients were lost to follow-up. Results: The overall proportion of H. pylori cure was 76%. Insufficient compliance (p < 0.001), a short duration of treatment (p < 0.001), smoking (p = 0.003), and omeprazole pretreatment (p = 0.041) were the significant independent factors predicting treatment failure, whereas advanced age (p = 0.002), high scores of grade and of activity of gastritis (p = 0.035 and p = 0.019. respectively), and gastric ulcer disease (p = 0.058) were independent factors predicting treatment success. Conclusions: Several patient- and therapy-related factors diminish or increase the rate of H. pylori cure obtained by omeprazole/amoxicillin. These should be considered in future studies comparing different treatment regimens for curing H. pylori infection and also when designing treatment regimens applicable for routine clinical practice. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00365529409094890 |
| Ending Page | 1075 |
| Page Count | 6 |
| Starting Page | 1070 |
| ISSN | 00365521 |
| e-ISSN | 15027708 |
| DOI | 10.3109/00365529409094890 |
| Journal | Scandinavian Journal of Gastroenterology |
| Issue Number | 12 |
| Volume Number | 29 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Journal of Gastroenterology Integrative and Complementary Medicine Helicobacter Pylori Peptic Ulcer Disease |
| Content Type | Text |
| Subject | Gastroenterology |
