NDLI: Determination of rifampicin and isoniazid in pharmaceutical formulations by HPLC

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Determination of rifampicin and isoniazid in pharmaceutical formulations by HPLC

Content Provider	Scilit
Author	Shah, Yateen Khanna, S. Jindal, K. C. Dighe, V. S.
Copyright Year	1992
Description	Journal: Drug Development and Industrial Pharmacy A liquid chromatographic procedure for the analysis of Rifampicin (RIF) and Isoniazid (INH) in pharmaceutical dosage forms utilizing reverse phase chromatography was developed. Isolation of analytes was carried out under isocratic conditions with a octadecylsilane column and an aqueous mobile phase containing Methanol (75%) and 0.02 M Disodium Hydrogen Orthophosphate (25%) with pH 4.5 adjusted with orthophosphoric acid. The detection was done at 254 nm. The method is unique in analysing Rifampicin precisely in combination with Isoniazid particularly in liquid formulation. The method is specific and can distinctly isolate the degradation product in suspension.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/03639049209040861
Ending Page	1596
Page Count	8
Starting Page	1589
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049209040861
Journal	Drug Development and Industrial Pharmacy
Issue Number	14
Volume Number	18
Language	English
Publisher	Informa UK Limited
Publisher Date	1992-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Chromatography Pharmaceutical
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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