NDLI: Transneuronal Down Regulation of Vestibulo-Ocular Neurons Following Vestibular Ablation

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Transneuronal Down Regulation of Vestibulo-Ocular Neurons Following Vestibular Ablation

Content Provider	Scilit
Author	Gacek, R. R. Schoonmaker, J. E.
Copyright Year	1997
Description	Journal: Acta Oto-Laryngologica Unilateral ablation of vestibular input causes lasting morphological changes bilaterally in superior vestibulo-ocular neurons (SVON). The present study was performed to see if these changes in SVON are more pronounced after bilateral vestibular neurectomy. Twenty-three SVON from both vestibular nuclei of 2 cats sacrificed 8 weeks after bilateral ablation were examined utilizing morphometric ultrastructural techniques. There was a significantly greater somal atrophy, loss of synaptic profiles, rough endoplasmic reticulum and polyribosomes compared to unilateral neurectomy. These changes indicate a down regulation that is proportional to the level of deafferentation and may account for functional deficits seen in the vestibulo-ocular reflex after peripheral ablation.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/00016489709114205
Ending Page	814
Page Count	5
Starting Page	810
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016489709114205
Journal	Acta Oto-Laryngologica
Issue Number	6
Volume Number	117
Language	English
Publisher	Informa UK Limited
Publisher Date	1997-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-Laryngologica Anesthesiology Ultrastructure Vestibular Ablation
Content Type	Text
Subject	Otorhinolaryngology

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