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The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes
| Content Provider | Scilit |
|---|---|
| Author | Oh, Kyung Joon Hong, Joon-Seok Romero, Roberto Yoon, Bo Hyun |
| Copyright Year | 2017 |
| Description | Journal: The Journal of Maternal-Fetal & Neonatal Medicine To evaluate the frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes. Amniotic fluid (AF) was retrieved from both sacs in 90 twin gestations with preterm labor and intact membranes (GA between 20+0 and 34+6 weeks). Preterm labor was defined as the presence of painful regular uterine contractions, with a frequency of at least 2 every 10 minutes, requiring hospitalization. Fluid was cultured and assayed for matrix metalloproteinase-8. Intra-amniotic inflammation was defined as an AF matrix metalloproteinase-8 concentration >23 ng/mL. The prevalence of intra-amniotic inflammation of at least 1 amniotic sac was 39% (35/90), while that of proven intra-amniotic infection for at least 1 amniotic sac was 10% (9/90). Intra-amniotic inflammation without proven microbial invasion of the amniotic cavity was found in 29% (26/90) of cases. Intra-amniotic inflammation was present in both amniotic sacs in 22 cases, in the presenting amniotic sac in 12 cases, and in the non-presenting amniotic sac in 1 case. Women with intra-amniotic inflammation observed in at least 1 amniotic sac and a negative AF culture for microorganisms had a significantly higher rate of adverse pregnancy outcome than those with a negative AF culture and without intra-amniotic inflammation (lower gestational age at birth, shorter amniocentesis-to-delivery interval, and significant neonatal morbidity). Importantly, there was no significant difference in pregnancy outcomes between women with intra-amniotic inflammation and a negative AF culture and those with a positive AF culture. Intra-amniotic inflammation is present in 39% of twin pregnancies with preterm labor and intact membranes and is a risk factor for impending preterm delivery and adverse outcome, regardless of the presence or absence of bacteria detected using cultivation techniques. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899042/pdf |
| Ending Page | 541 |
| Page Count | 15 |
| Starting Page | 527 |
| ISSN | 14767058 |
| e-ISSN | 14764954 |
| DOI | 10.1080/14767058.2017.1384460 |
| Journal | The Journal of Maternal-Fetal & Neonatal Medicine |
| Issue Number | 4 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-02-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of Maternal-Fetal & Neonatal Medicine Obstetrics and Gynecology Intra-amniotic Infection Intra-amniotic Inflammation Matrix Metalloproteinase-8 Preterm Labor Preterm Birth Twin Pregnancy |
| Content Type | Text |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
