“I will survive”: A tale of bacteriophage-bacteria coevolution in the gut

Content Provider	Scilit
Author	Sordi, Luisa De Lourenço, Marta Debarbieux, Laurent
Copyright Year	2018
Description	Journal: Gut Microbes Viruses that infect bacteria, or bacteriophages, are among the most abundant entities in the gut microbiome. However, their role and the mechanisms by which they infect bacteria in the intestinal tract remain poorly understood. We recently reported that intestinal bacteria are an evolutionary force, driving the expansion of the bacteriophage host range by boosting the genetic variability of these viruses. Here, we expand these observations by studying antagonistic bacteriophage-bacteria coevolution dynamics and revealing that bacterial genetic variability is also increased under the pressure of bacteriophage predation. We propose a model showing how the expansion of bacteriophage-bacteria infection networks is relative to the opportunities for coevolution encountered in the intestinal tract. Our data suggest that predator-prey dynamics are perpetuated and differentiated in parallel, to generate and maintain intestinal microbial diversity and equilibrium.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363074/pdf
Ending Page	99
Page Count	8
Starting Page	92
ISSN	19490976
e-ISSN	19490984
DOI	10.1080/19490976.2018.1474322
Journal	Gut Microbes
Issue Number	1
Volume Number	10
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-01-02
Access Restriction	Open
Subject Keyword	Journal: Gut Microbes Mathematical and Computational Biology Bacterial Populations Phage-bacteria Coevolution Microbial Diversity Gastrointestinal Tract Defining/profiling Gut Microbiome
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Gastroenterology Microbiology Microbiology (medical)