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Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response
| Content Provider | Scilit |
|---|---|
| Author | Peng, Jie Hasserjian, Robert P. Tang, Guilin Patel, Keyur P. Goswami, Maitrayee Jabbour, Elias J. Garcia-Manero, Guillermo Medeiros, L. Jeffrey Wang, Sa A. |
| Copyright Year | 2016 |
| Description | Journal: Leukemia & Lymphoma We studied 28 patients with myelodysplastic syndromes (MDS) who showed a rise of bone marrow (BM) erythroids to ≥50% following 3 cycles (1-60) of hypomethylating agent (HMA) therapy. If BM blasts calculated as a percentage of non-erythroids, 12 (42.9%) patients met the diagnostic criteria for acute erythroleukemia, erythroid/myeloid (AEL). However, none of the patients showed clonal cytogenetic evolution or new mutations. When compared to 47 de novo AEL patients, these 12 patients were less anemic and thrombocytopenic, had less complex karyotypes (p=0.044), and showed a longer survival, either calculated from diagnosis (p<0.001) or from the time of AEL (p=0.005). These findings illustrate that ≥50% erythroids may appear in BM post HMA therapy, likely a combination of reduction of BM granulocytes (p<0.001) and promotion of normal or abnormal erythroid proliferation. Enumeration of blasts as a percentage of non-erythroid cells may lead to a diagnosis of AEL and mis-interpretation as disease progression. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10428194.2015.1079318 |
| Ending Page | 819 |
| Page Count | 8 |
| Starting Page | 812 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2015.1079318 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 4 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-02-08 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Acute Erythroid Leukemia Erythroid Predominance Hypomethylating Agents Myelodysplastic Syndrome |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
