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Robust Optimization of Biological Protocols
| Content Provider | Scilit |
|---|---|
| Author | Flaherty, Patrick Davis, Ronald W. |
| Copyright Year | 2015 |
| Description | Journal: Technometrics When conducting high-throughput biological experiments, it is often necessary to develop a protocol that is both inexpensive and robust. Standard approaches are either not cost-effective or arrive at an optimized protocol that is sensitive to experimental variations. Here, we describe a novel approach that directly minimizes the cost of the protocol while ensuring the protocol is robust to experimental variation. Our approach uses a risk-averse conditional value-at-risk criterion in a robust parameter design framework. We demonstrate this approach on a polymerase chain reaction protocol and show that our improved protocol is less expensive than the standard protocol and more robust than a protocol optimized without consideration of experimental variation. |
| Related Links | http://europepmc.org/articles/pmc4582800?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582800/pdf |
| Ending Page | 244 |
| Page Count | 11 |
| Starting Page | 234 |
| ISSN | 00401706 |
| e-ISSN | 15372723 |
| DOI | 10.1080/00401706.2014.915890 |
| Journal | Technometrics |
| Issue Number | 2 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Technometrics Biochemical Research Analysis of Designed Experiments Experimental Design Quality Control/process Improvement Response Surface Methods Robust Parameter Design. |
| Content Type | Text |
| Subject | Applied Mathematics Statistics and Probability Modeling and Simulation |
