NDLI: Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways

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Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways

Content Provider	Scilit
Author	Feng, Shuang Cong, Hui Ji, Lei
Copyright Year	2020
Description	Journal: Drug design, development and therapy Introduction: Osteoarthritis (OA), a chronic joint disease, combines with massive inflammation and plays a vital role in cartilage degeneration. The main strategy in clinic is controlling inflammation, thereby treating osteoarthritis. Salvianolic acid A (SAA) is a type of phenolic acid, derived from a traditional chinese herbal medicine Danshen that is extensively used clinically. Methods and Results: We observed the anti-inflammatory and antiarthritic effects of SAA in IL-1β-stimulated cells. We found that SAA evidently decreased the expression of mainly inflammatory factors, exerted the remarkable effects of anti-inflammation and anti-arthritis. Furthermore, SAA inhibited the expression of Matrix metalloproteinases (MMP1, MMP13), and ADAMTS-5 and raised the synthesis of collagen II and aggrecan. Additionally, the results indicated that SAA gave rise to the effects by down-regulation of NF-κB and p38/MAPK pathways. Discussion: Our study demonstrates that SAA may be a promising anti-inflammatory for the treatment of OA in clinic.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217308/pdf https://www.dovepress.com/getfile.php?fileID=57963
Ending Page	1778
Page Count	8
Starting Page	1771
e-ISSN	11778881
DOI	10.2147/dddt.s235857
Journal	Drug design, development and therapy
Volume Number	ume 14
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-05-01
Access Restriction	Open
Subject Keyword	Journal: Drug design, development and therapy Integrative and Complementary Medicine Nf-κb Pathway Osteoarthritis Salvianolic Acid A
Content Type	Text

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