NDLI: 4E-BP1, a multifactor regulated multifunctional protein

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4E-BP1, a multifactor regulated multifunctional protein

Content Provider	Scilit
Author	Qin, Xiaoyu Jiang, Bin Zhang, Yanjie
Copyright Year	2016
Description	Journal: Cell Cycle Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/15384101.2016.1151581?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845917/pdf
Ending Page	786
Page Count	6
Starting Page	781
ISSN	15384101
e-ISSN	15514005
DOI	10.1080/15384101.2016.1151581
Journal	Cell Cycle
Issue Number	6
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-02-22
Access Restriction	Open
Subject Keyword	Journal: Cell Cycle Biochemistry and Molecular Biology Eukaryotic Translation Initiation Factor 4e (eif4e)-binding Protein 1 Overexpression Phosphorylation
Content Type	Text
Subject	Cell Biology Developmental Biology Medicine Molecular Biology

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