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Dstacis required for normal circadian activity rhythms inDrosophila
| Content Provider | Scilit |
|---|---|
| Author | Hsu, I-Uen Linsley, Jeremy W. Varineau, Jade E. Shafer, Orie T. Kuwada, John Y. |
| Copyright Year | 2018 |
| Description | Journal: Chronobiology international The genetic, molecular and neuronal mechanism underlying circadian activity rhythms is well characterized in the brain of Drosophila. The small ventrolateral neurons $(s-LN_{V}$s) and pigment dispersing factor (PDF) expressed by them are especially important for regulating circadian locomotion. Here we describe a novel gene, Dstac, which is similar to the stac genes found in vertebrates that encode adaptor proteins, which bind and regulate L-type voltage-gated $Ca^{2+}$ channels (CaChs). We show that Dstac is coexpressed with PDF by the $s-LN_{V}$s and regulates circadian activity. Furthermore, the L-type CaCh, Dmca1D, appears to be expressed by the $s-LN_{V}$s. Since vertebrate Stac3 regulates an L-type CaCh we hypothesize that Dstac regulates Dmca1D in $s-LN_{V}$s and circadian activity. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103890/pdf |
| Ending Page | 1026 |
| Page Count | 11 |
| Starting Page | 1016 |
| ISSN | 07420528 |
| e-ISSN | 15256073 |
| DOI | 10.1080/07420528.2018.1454937 |
| Journal | Chronobiology international |
| Issue Number | 7 |
| Volume Number | 35 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-04-05 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chronobiology international Cell Biology Pigment Dispersing Factor Circadian Rhythm L-type Calcium Channel |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
