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The Control of Drug Release from Conventional Melt Granulation Matrices
| Content Provider | Scilit |
|---|---|
| Author | Flanders, P. Dyer, G. A. |
| Copyright Year | 1987 |
| Description | Journal: Drug Development and Industrial Pharmacy Sustained release potassium chloride tablets were prepared using a melt granulation formulation in a Baker Perkins Granulator. Parts of the validation for this manufacturing process are highlighted in this paper including granulation end point temperature, incorporation of extragranular excipients, amount of wax in the formulation, granule cooling rate and scale of the operation. A number of other factors have been studied which are not Included here although they are no less important. The release of potassium chloride from tablets was found to be dependent on the wax level and the amount of extragranular excipients (“wicklng agent”). Within the controlled production process, any variation in granulation end point temperature and granule cooling rate should not have any significant effect. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048709068366 |
| Ending Page | 1022 |
| Page Count | 22 |
| Starting Page | 1001 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048709068366 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 6 |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1987-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Melt Granulation Granulation Matrices Conventional Melt Drug Release |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
