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Cisplatin and 5-Fu Combined with Radiotherapy and Surgery in the Treatment of Squamous Cell Carcinoma of the Esophagus Palliative Effects and Tumor Response
| Content Provider | Scilit |
|---|---|
| Author | Mercke, C. Albertsson, M. Hambraeus, G. Tennvall, J. Lillo-Gil, R. Samuelsson, L. Willén, R. Ranstam, Jonas |
| Copyright Year | 1991 |
| Description | Journal: Acta Oncologica The combination of cisplatin (90-120mg/m2) and 5-fluorouracil (5-FU) (1 000 mg/m2/day in continuous infusion for five days) was given for 2-3 cycles, prior to combined radiotherapy and surgery, to 73 patients with esophageal squamous cell carcinoma, 60 with limited disease (LD), and 13 with extensive disease (ED) (i.e. with metastasis) of whom 3 had recurrent disease. Before preoperative radiotherapy among 60 LD patients, 12 (20%) had complete response, 21 (35%) partial response, 25 (42%) had stable disease, and 2 (3%) progressive disease. Swallowing was improved in 35/73 (48%) of the cases. in the resected specimens, no tumor was found in 8/53 (15%) of the cases, microscopic tumor in 18/53 (34%) and macroscopic tumor in 27/53 (51%). in the ED group, complete response of distant metastases was obtained in 6/13 (48%) of the patients, one of whom is still alive with no evidence of disease 62 months after the start of treatment. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/02841869109092429 |
| Ending Page | 622 |
| Page Count | 6 |
| Starting Page | 617 |
| ISSN | 0284186X |
| e-ISSN | 1651226X |
| DOI | 10.3109/02841869109092429 |
| Journal | Acta Oncologica |
| Issue Number | 5 |
| Volume Number | 30 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oncologica Radiology, Nuclear Medicine and Imaging Squamous Cell Carcinoma Radiotherapy |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Hematology Oncology |
