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Recent Advances in Cell Biology, Diagnosis and Therapy of Gastrointestinal Stroma Tumor (GIST)
| Content Provider | Scilit |
|---|---|
| Author | Logrono, Roberto Jones, Dennie V. Faruqi, Sohaib Bhutani, Manoop S. |
| Copyright Year | 2004 |
| Description | Journal: Cancer Biology & Therapy The understanding of mesenchymal neoplasms of the gastrointestinal tract has evolved dramatically over the last two decades since gastrointestinal stromal tumor (GIST) was described as the most common stromal tumor arising anywhere from the esophagus to the ano-rectum. Although morphologically similar to other benign and malignant smooth muscle and neural stromal neoplasms, GIST constitutes a distinct group of rare gastrointestinal tract tumors that originate from the interstitial cells of Cajal, regulators of gut peristalsis that normally express CD117, which is the product of the c-KIT proto-oncogene that encodes a tyrosine kinase receptor that regulates cellular proliferation in GISTs. Virtually all GISTs occur from mutations of the c-KIT oncogene and exhibit consistent expression of c-KIT (CD117), which is considered the most specific criterion for a diagnosis of GIST. Gastrointestinal stromal tumors vary in their behavior and several features have to be considered to assess their malignant potential. The advent of sophisticated imaging techniques for the evaluation and sampling of stromal tumors of the gastrointestinal tract has resulted in improved detection of GISTs. The identification of a novel tumor-specific target in c-KIT resulted in the development of a tyrosine kinase-inhibitor (imatinib mesylate) that provides an encouraging option for treating GISTs. This article reviews recent advances in the understanding of the cell biology, diagnosis, and therapy of GISTS. |
| Related Links | https://www.landesbioscience.com/journals/cbt/logrono3-3.pdf |
| Ending Page | 258 |
| Page Count | 8 |
| Starting Page | 251 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.3.3.615 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 3 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2004-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Cell Tissue Engineering Gastrointestinal Tract Stromal Tumor |
| Content Type | Text |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
