NDLI: Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis

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Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis

Content Provider	Scilit
Author	Gulias-Cañizo, Rosario Benatti, Andres Wit-Carter, Guillermo De Hernández-Quintela, Everardo Sánchez-Huerta, Valeria
Copyright Year	2020
Description	Journal: Clinical Ophthalmology Purpose: To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis. Design: Observational cohort study. Participants: Forty-two eyes from 41 patients with treatment-resistant infectious keratitis. Methods: Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and p values lower than 0.05 were considered statistically significant. Results: Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031). Conclusion: As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.
Related Links	https://www.dovepress.com/getfile.php?fileID=65001
Ending Page	4457
Page Count	7
Starting Page	4451
ISSN	11775467
e-ISSN	11775483
DOI	10.2147/opth.s284306
Journal	Clinical Ophthalmology
Volume Number	ume 14
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-12-01
Access Restriction	Open
Subject Keyword	Journal: Clinical Ophthalmology Ophthalmology Cross-linking Resistant Keratitis
Content Type	Text
Subject	Ophthalmology

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