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Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide»
| Content Provider | Scilit |
|---|---|
| Author | Souayed, Nouha Chennoufi, Malek Boughattas, Fida Haouas, Zohra Maaroufi, Khira Miled, Abdelhedi Ben-Attia, Mosaddok Aouam, Karim Reinberg, Alain Boughattas, Naceur A. |
| Copyright Year | 2015 |
| Description | Journal: Chronobiology international The circadian time is an important process affecting both pharmacokinetics and pharmacodynamics of drugs. Consequently, the desired and/or undesired effects vary according to the time of drug administration in the 24 h scale. This study investigates whether the toxicity in liver as well as oxidative stress varies according to the circadian dosing-time of isoniazid (INH) in mice. A potentially toxic INH dose (120 mg/kg) was injected by i.p. route to different groups of animals at three different circadian times: 1, 9, and 17 Zeitgeber time (ZT). INH administration at 1 ZT resulted in a maximum hepatotoxicity assessed by the significant increase in both serum transaminase (ALAT: alanine aminotransferase) and (ASAT: aspartate aminotransferase) and antioxidant enzyme activities (catalase: CAT and superoxide dismutase: SOD). The highest malondialdehyde (MDA) level indicating an induction of lipid peroxidation resulting in oxidative damage was also observed at 1 ZT. Liver histopathology from INH groups at 9 ZT and at 1 ZT showed moderate to severe cytoplasma vacuolation, hepatocyte hypertrophy, ballooning, and necrosis. The circadian variation in INH toxicity may help realize a chronotherapy protocol in humans based on the selection of the best time associated to optimal tolerance or least side effects. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/07420528.2015.1078808 |
| Ending Page | 1210 |
| Page Count | 10 |
| Starting Page | 1201 |
| ISSN | 07420528 |
| e-ISSN | 15256073 |
| DOI | 10.3109/07420528.2015.1078808 |
| Journal | Chronobiology international |
| Issue Number | 9 |
| Volume Number | 32 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-09-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chronobiology international Histopathology Circadian Rhythm |
| Content Type | Text |
| Subject | Physiology Physiology (medical) |
