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Toxicity of chemical components of fine particles inhaled by aged rats: effects of concentration.
| Content Provider | Scilit |
|---|---|
| Author | Kleinman, Michael T. Hyde, Dallas M. Bufalino, Charles Basbaum, Carol Bhalla, Deepak K. Mautz, William J. |
| Copyright Year | 2003 |
| Description | Journal: Journal of the Air & Waste Management Association This study tested the hypothesis that exposure to mixtures containing fine particles and ozone $(O_{3}$) would cause pulmonary injury and decrements in functions of immunological cells in exposed rats (22–24 months old) in a dose-dependent manner. Rats were exposed to high and low concentrations of ammonium bisulfate and elemental carbon and to 0.2 ppm $O_{3}$. Control groups were exposed to purified air or $O_{3}$ alone. The biological end points measured included histopathological markers of lung injury, bronchoalveolar lung fluid proteins, and measures of the function of the lung's innate immuno-logical defenses (macrophage antigen-directed phagocytosis and respiratory burst activity). Exposure to $O_{3}$ alone at 0.2 ppm did not result in significant changes in any of the measured end points. Exposures to the particle mixtures plus $O_{3}$ produced statistically significant changes consistent with adverse effects. The low-concentration mixture produced effects that were statistically significant compared to purified air but, with the exception of macrophage Fc receptor binding, exposure to the high-concentration mixture did not. The effects of the low- and high-concentration mixtures were not significantly different. The study supports previous work that indicated that particle + $O_{3}$ mixtures were more toxic than $O_{3}$ alone. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.1080/10473289.2003.10466262?needAccess=true |
| Ending Page | 1087 |
| Page Count | 8 |
| Starting Page | 1080 |
| ISSN | 10962247 |
| e-ISSN | 21622906 |
| DOI | 10.1080/10473289.2003.10466262 |
| Journal | Journal of the Air & Waste Management Association |
| Issue Number | 9 |
| Volume Number | 53 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2003-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of the Air & Waste Management Association Concentration Mixture |
| Content Type | Text |
| Subject | Atmospheric Science Pollution Waste Management and Disposal Management, Monitoring, Policy and Law |
