NDLI: New dilemmas in small-cell lung cancer TNM clinical staging

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New dilemmas in small-cell lung cancer TNM clinical staging

Content Provider	Scilit
Author	Zarogoulidis, Paul Zarogoulidis, Konstantinos Latsios, Dimitris Eleftheriadou, Ellada Boutsikou, Efimia Darwiche, Kaid Hohenforst-Schmidt, Wolfgang Porpodis, Konstantinos Kontakiotis, Theodore Antoniou, Nick
Copyright Year	2013
Description	Journal: OncoTargets and therapy Background: Many patients with limited disease (LD) behave similarly to those with extensive disease (ED) from a prognostic point of view. On the other hand, a proportion of patients with ED small-cell lung cancer (SCLC) behave similarly to those with LD. Patients and methods: In this retrospective study analysis, 764 patients with proven SCLC were included and managed with the same therapeutic protocols. Of these patients, 278 (36.4%) had LD, while 486 (63.6%) had ED. Results: No statistically significant difference was observed for survival for IA and IB disease stages (P = 0.254) and between IIA and IIB stages (P = 0.256) according to the new tumor, node, metastasis (TNM) staging classification classification. In addition, no statistical significant difference was observed for survival between patients with (IIA + IIB) and IIIA (P = 0.951), (IIA + IIIA, P = 0.658), and (IIB + IIIA, P = 0.573) stages. Statistical significant difference was observed for survival among the LD SCLC patients with (IA + IB), (IIA + IIB + IIIA), and IIIB stages (P < 0.001). Similarly, statistical significance was observed for ED SCLC patients with (IIA + IIB + IIIA), IIIB, and IV stages (P < 0.001). Conclusions: Although stratification of SCLC patients in LD and ED is generally satisfactory, the TNM staging system is recommended for more detailed prognostic information and treatment evaluation in these patients.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660153/pdf https://www.dovepress.com/getfile.php?fileID=16106
Ending Page	547
Page Count	9
Starting Page	539
ISSN	11786930
DOI	10.2147/ott.s44201
Journal	OncoTargets and therapy
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-05-01
Access Restriction	Open
Subject Keyword	Journal: OncoTargets and therapy Medical Laboratory Technology Small-cell Lung Cancer
Content Type	Text
Subject	Pharmacology (medical) Oncology

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