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The effect of decitabine dose modification and myelosuppression on response and survival in patients with myelodysplastic syndromes
| Content Provider | Scilit |
|---|---|
| Author | Jabbour, Elias Garcia-Manero, Guillermo Cornelison, A. Megan Cortes, Jorge Ravandi, Farhad Daver, Naval Kadia, Tapan Teng, Angela Kantarjian, Hagop |
| Copyright Year | 2014 |
| Description | Journal: Leukemia & Lymphoma Myelosuppression in myelodysplastic syndromes (MDS) is associated with the hypomethylating agent decitabine. A retrospective pooled analysis of two decitabine clinical trials in patients with MDS conducted Cox regression analyses of red blood cell or platelet dependence, myelosuppression, dose modification, cycle delay or dose reduction, and survival effects. In 182 patients, baseline platelet dependence was a predictor for dose modification, reduction or delay, and death (modification: p = 0.006, hazard ratio [HR] = 2.04; reduction/delay: p = 0.011, HR = 2.00; death: p = 0.003, HR = 1.94). Patients with dose modifications had significantly higher overall response rates versus those with none (22% vs. 10%; p = 0.015). Patients with no dose modifications had faster progression to acute myeloid leukemia (AML) versus patients with dose modifications (p = 0.004). Without dose modifications, patients tended to drop out due to disease progression or other reasons. Decitabine dose modifications on treatment may indicate response to treatment. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297591/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2014.914192 |
| Ending Page | 394 |
| Page Count | 5 |
| Starting Page | 390 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2014.914192 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 2 |
| Volume Number | 56 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Myelodysplastic Syndromes Retrospective Study |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
