NDLI: Macrolide Antibiotics

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Macrolide Antibiotics

Content Provider	Scilit
Author	Riviere, J. Edmond. Craigmill, Arthur L. Sundlof, Stephen F.
Copyright Year	2018
Description	The macrolides are a group of antibiotics produced by species of Streptomyces. The primary clinically used macrolide is erythromycin and is often considered the representative drug for this class. Tylosin is also extensively utilized in veterinary medicine. The other available macrolides are older compounds and are not as safe for routine use as are erythromycin or tylosin. The macrolides are used in veterinary practice as feed additives for growth promotion, as coccidiostats, and in the treatment of respiratory tract and skin infections. Macrolides are effectively absorbed after oral administration. Erythromycin base is susceptible to acid degradation, but is absorbed well orally from enteric-coated or various salt preparations. Tylosin is more acid stable and is absorbed in the base form. The macrolides generally distribute well throughout body fludis. Documentation is lacking in the veterinary literature, although some clinical evidence suggests that horses are sensitive to the gastrointestinal adverse effects and possibly are susceptible to the erythromycin-induced cholestatic hepatitis. Book Name: Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781351071055-5&type=chapterpdf
Ending Page	262
Page Count	34
Starting Page	229
DOI	10.1201/9781351071055-5
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-01-18
Access Restriction	Open
Subject Keyword	Book Name: Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials Macrolides Horses Erythromycin Antibiotics Treatment Veterinary Tylosin Absorbed Susceptible
Content Type	Text
Resource Type	Chapter

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