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Retinal Tissue Thickness is Reduced in Diabetic Peripheral Neuropathy
| Content Provider | Scilit |
|---|---|
| Author | Srinivasan, Sangeetha Pritchard, Nicola Vagenas, Dimitrios Edwards, Katie Sampson, Geoff P. Russell, Anthony W. Malik, Rayaz A. Efron, Nathan |
| Copyright Year | 2016 |
| Description | Journal: Current Eye Research Aim: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness. Methods: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0–10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and $HbA_{1c}$ levels. Results: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and $HbA_{1c}$ levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04). Conclusions: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates. |
| Related Links | https://eprints.qut.edu.au/80061/1/Sangeeta_Srinivasan_IDF_version2.0.pdf https://www.tandfonline.com/doi/pdf/10.3109/02713683.2015.1119855 |
| Ending Page | 1366 |
| Page Count | 8 |
| Starting Page | 1359 |
| ISSN | 02713683 |
| e-ISSN | 14602202 |
| DOI | 10.3109/02713683.2015.1119855 |
| Journal | Current Eye Research |
| Issue Number | 10 |
| Volume Number | 41 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-10-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Eye Research Ophthalmology Diabetic Peripheral Neuropathy Ganglion Cell Complex Neuropathy Disability Score Retinal Nerve Fiber Layer Retinal Thickness |
| Content Type | Text |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
