NDLI: 1 For individuals

Please wait, while we are loading the content...

1 For individuals

Content Provider	Scilit
Author	Rawlins, Michael
Copyright Year	2011
Description	In some instances a particular intervention is eective only in subgroups of individuals with a particular disorder. Targeting therapy in such a way is not new. Appropriate antimicrobial therapy has, for many years, been based wherever possible on the nature of the infectious agent and its sensitivity pattern. Advances in genomic medicine and molecular biology, however, are leading to redenitions of disease and a more personalized approach to therapeutics.3 Trastuzumab, for instance, is eective only in women with breast cancer whose tumour cells express the human epidermal growth factor 2 (Her2) receptor.4 Similarly, the eects of cetuximab on overall survival in individuals with advanced colorectal cancer are dependent on the presence of the wildtype Kras epidermal growth factor receptor rather than the mutated form:5 the hazard ratio for overall survival was 0.55 (95% condence interval (CI) 0.41 to 0.74) in tumours expressing the wild-type Kras, compared with 0.98 (95% CI 0.70 to 1.37) in tumours expressing the mutated form. Book Name: Therapeutics, Evidence and Decision-Making
Related Links	https://content.taylorfrancis.com/books/download?dac=C2012-0-10428-X&isbn=9780429102820&doi=10.1201/b13485-34&format=pdf
Ending Page	221
Page Count	7
Starting Page	215
DOI	10.1201/b13485-34
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-07-29
Access Restriction	Open
Subject Keyword	Book Name: Therapeutics, Evidence and Decision-Making General Medicine Epidermal Growth Mutated Form
Content Type	Text
Resource Type	Chapter

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in