NDLI: Squamous Metaplasia of the Middle Ear Epithelium

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Squamous Metaplasia of the Middle Ear Epithelium

Content Provider	Scilit
Author	Kuijpers, W. Vennix, P. P. C. A. Peters, Theo Ramaekers, F. C. S.
Copyright Year	1996
Description	Journal: Acta Oto-Laryngologica This study deals with the expression of cytokeratins (Cks) in squamous cell metaplastic lesions in rat and human middle ear. In rats, squamous metaplastic lesions could be induced during chronic otitis media. The histological features of these lesions were similar to those observed in the human middle ear. Immunohistochemistry revealed that squamous cell metaplasia in both rat and human middle ear is characterised by a loss of simple epithelial cell related Cks and the appearance of Cks characteristic of stratified and cornifying epithelia. This indicates a true change in the differentiation of the middle ear epithelium. It is concluded that the Ck profile of the cholesteatoma matrix cannot be used as a variable to decide whether the origin of cholesteatomas is epidermal or metaplastic. This rat model is suitable for studying squamous cell metaplasia in relation to cholesteatoma genesis.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00016489609137844
Ending Page	298
Page Count	6
Starting Page	293
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016489609137844
Journal	Acta Oto-Laryngologica
Issue Number	2
Volume Number	116
Language	English
Publisher	Informa UK Limited
Publisher Date	1996-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-Laryngologica Otorhinolaryngology Middle Ear Epithelium
Content Type	Text
Subject	Otorhinolaryngology

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