NDLI: HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma

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HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma

Content Provider	Scilit
Author	Liu, Ning Wang, Ziyu Liu, Dachao Xie, Peng
Copyright Year	2019
Description	Journal: OncoTargets and therapy Purpose: Differentially expressed long non-coding ribonucleic acids (lncRNAs) have been reported as a key factor of glioma carcinogenesis, but the underlying mechanism involved is still unknown. Materials and methods: In the present study, lncRNA HOXC13 antisense RNA (HOXC13-AS) was identified as a potential oncogene in glioma, and Western blotting, wound healing and Transwell assays were carried out to explore the effects of HOXC13-AS on the epithelial-mesenchymal transition (EMT) process as well as the migration and invasion of glioma cells. Results: A further mechanistic study showed that HOXC13-AS sponged miR-122-5p to indirectly regulate SATB1 expression and affect the EMT process via the Wnt/β-catenin pathway. Meanwhile, the promoter activity was significantly increased via c-Myc, a key factor of the Wnt/β-catenin pathway, thus forming a positive HOXC13-AS-miR-122-5p-SATB1-c-Myc feedback loop to drive the malignant behavior in glioma. Discussion: This study evidences the constitutive HOXC13-AS-miR-122-5p-SATB1-c-Myc feedback loop and provides a potential therapeutic target for glioma treatment.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731462/pdf https://www.dovepress.com/getfile.php?fileID=52444
Ending Page	7173
Page Count	9
Starting Page	7165
ISSN	11786930
DOI	10.2147/ott.s220027
Journal	OncoTargets and therapy
Volume Number	ume 12
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-09-01
Access Restriction	Open
Subject Keyword	Journal: OncoTargets and therapy Competing Endogenous Rna Epithelial-mesenchymal Transition
Content Type	Text
Subject	Pharmacology (medical) Oncology

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