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D-Cycloserine and Cocaine Cue Reactivity: Preliminary Findings
| Content Provider | Scilit |
|---|---|
| Author | Price, Kimber L. Rae-Clark, Aimee L. Mc Saladin, Michael E. Maria, Megan M. Moran-Santa DeSantis, Stacia M. Back, Sudie E. Brady, Kathleen T. |
| Copyright Year | 2009 |
| Description | Journal: The American journal of drug and alcohol abuse Background: D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders. Objectives: This preliminary study investigates DCS pretreatment on response to cocaine cues in cocaine-dependent subjects. Methods: Ten cocaine-dependent subjects were randomly assigned to receive either 50 mg DCS or matching placebo two hours before each of two 1-hour cocaine cue exposure sessions one day apart. HR and craving ratings were obtained before and during cue exposure sessions. Results: There was a trend towards increased craving to cocaine cues in cocaine-dependent individuals after administration of DCS. Conclusions: The administration of DCS prior to cue exposure sessions may facilitate response activation. Scientific Significance: While facilitation of extinction-based learning by DCS may have therapeutic potential for cocaine dependence, this drug may exhibit a different profile in cocaine-dependent individuals as compared to those with anxiety disorders. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805418/pdf https://www.tandfonline.com/doi/pdf/10.3109/00952990903384332 |
| Ending Page | 438 |
| Page Count | 5 |
| Starting Page | 434 |
| ISSN | 00952990 |
| e-ISSN | 10979891 |
| DOI | 10.3109/00952990903384332 |
| Journal | The American journal of drug and alcohol abuse |
| Issue Number | 6 |
| Volume Number | 35 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-12-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: The American journal of drug and alcohol abuse Psychiatry and Mental Health Cue Reactivity D-cycloserine |
| Content Type | Text |
| Subject | Clinical Psychology Psychiatry and Mental Health |
